DiDonato has served as the face of numerous beauty and fashion campaigns, including Maybelline New York cosmetics, and Aqua di Gioia, the bestselling fragrance by Giorgio Armani. Inez and Vinoodh captured DiDonato for a series of Miu Miu promotions, and Mert and Marcus photographed her for a Brian Atwood advertising campaign. Additionally, the doe-eyed beauty has graced the covers of Vogue Paris, photographed by David Sims, as well as the covers Vogue Turkey, and Vogue España.

Recently, she fronted WSJ., The Wall Street Journal's luxury style publication, as well as appeared in select fashion stories for the international editions of Numéro. Select runway appearances, meanwhile, include Balmain, and Erin Wasson's RVCA collection.